54 articles - From Friday Aug 23 2024 to Friday Aug 30 2024
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Inflamm Bowel Dis |
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Consensus Statement on Managing Anxiety and Depression in Individuals with Inflammatory Bowel Disease. Mental healthcare and support for IBD patients is critical; the statements included in this article represent practical considerations for IBD healthcare professionals in addressing key issues on provider awareness, knowledge and behaviors, screening and treatment resources, and patient education. |
| Liver Transpl |
meta-analyses and systematic reviews
| Inflamm Bowel Dis |
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Systematic Review: Practices and Programs in Inflammatory Bowel Disease Transition Care. Transition- and medical-related outcomes for adolescents with IBD have been shown to benefit from structured transition programs but practices vary greatly between centers. There is no current standardized transition model for patients with IBD prompting further research to guide future development of guidelines and models of care. |
| J Crohns Colitis |
Prevalence of Sexual Dysfunction In Inflammatory Bowel Disease: Systematic Review and Meta-Analysis. We demonstrated high prevalence of SD in IBD patients, especially in women. Encouraging gastroenterologists to screen for, and treat, these disorders with a holistic approach might improve quality of life of patients with IBD. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
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Association between dietary magnesium intake and incident chronic kidney disease : A prospective observational cohort study. Lower dietary magnesium intake was associated with a higher risk of incident CKD in adults with clinically normal kidney function. Further controlled studies are required to establish the potential benefit of adequate magnesium intake. |
Association of ultra-processed food consumption with risk of rheumatoid arthritis: A retrospective cohort study in the UK Biobank. Higher UPF consumption was associated with an increased risk of RA, which may be mediated by inflammation, lipids, and liver enzymes. Lower UPF consumption is recommended to reduce RA incidence. |
Associations Between Different Coffee Types, Neurodegenerative Diseases, and Related Mortality: Findings from a Large Prospective Cohort Study. Higher intake of caffeinated coffee, particularly the unsweetened variety, was associated with reduced risks of ADRD and PD. No such associations were observed for sugar-sweetened or artificially sweetened coffee. |
Deep serum lipidomics identifies evaluative and predictive biomarkers for individualized glycemic responses following low-energy diet-induced weight loss: a PREVIEW sub-study. Newly discovered serum lipidomic alterations and the associated changes in lipid-clinical variables suggest broad metabolic reprogramming related to diet-mediated glycemic control. Novel lipid predictors of glycemic outcomes could facilitate early stratification of individuals with prediabetes who are metabolically less responsive to weight loss, enabling more tailored intervention strategies beyond one-size-fits-all lifestyle modification advice. The PREVIEW lifestyle intervention study was registered at clinicaltrials.gov as NCT01777893 ( |
Diet Order Significantly Affects Energy Balance For Diets Varying In Macronutrients But Not Ultra-Processing In Crossover Studies Without A Washout Period. Diet order significantly affected energy intake, body weight, and body fat in a 4-week crossover inpatient diet study varying in macronutrients, but not in a similarly structured study varying in ultra-processed foods. Clinical trial registration |
Dietaryindex: A User-Friendly and Versatile R Package for Standardizing Dietary Pattern Analysis in Epidemiological and Clinical Studies. Dietaryindex is a user-friendly, versatile, and validated informatics tool for standardized dietary index calculations. We have open-sourced al the validation files and codes with detailed tutorials on GitHub ( |
Plasma n6 polyunsaturated fatty acid levels and risk for total and cause-specific mortality: A prospective observational study from the UK Biobank. These findings highlight the profound differences in health-related outcomes related to LA and non-LA n6 PUFA levels and underscore the inappropriateness of treating n-6 PUFAs as a homogenous class with respect to health outcomes. They also support recommendations to maintain (if not increase) current LA intakes. |
The Role of Nutritional Factors in Transitioning between Early, Mid and Late Stages of Age-Related Macular Degeneration: prospective longitudinal analysis. Increased consumption of green leafy vegetables, LZ, and fish nutritionally rich in ω-3 fatty acids during the initial stages of AMD may reduce rates of progression to higher severity of this debilitating disease. Clinical trial NCT00594672. |
| Inflamm Bowel Dis |
Communicating Information Regarding IBD Remission to Patients: Evidence From a Survey of Adult Patients in the United States. Our study confirms that patients tend to define remission in terms of resolving symptoms. We found little evidence of barriers preventing patients from discussing remission with their healthcare professionals. This suggests that educational material could be used to resolve this discrepancy in understanding. |
Food-Based Interventions as Therapy for Inflammatory Bowel Disease: Important Steps in Diet Trial Design and Reporting of Outcomes. Diet therapy trials should adhere to similar rigorous quality standards used to develop other IBD therapies. Therefore, a set of practical recommendations was generated to provide the authors' perspective to help inform the future design of high-quality IBD diet trials. |
Psychological Distress Is Associated With Inflammatory Bowel Disease Manifestation and Mucosal Inflammation. A significantly higher psychological distress was identified in IBD patients. CD patients with increased ileal expression of IL17F and IL23A genes had higher PSS and HADS, suggesting a potential interplay between psychological distress and inflammation. |
Sarcopenia Is a Risk Factor for Postoperative Complications Among Older Adults With Inflammatory Bowel Disease. Sarcopenia, as measured by SMI, is associated with an increased risk of postoperative complications among older adults with IBD. Measurement of SMI from preoperative imaging can help risk stratify older adults with IBD undergoing intestinal resection. |
Self-Compassion in Adolescents and Young Adults With Inflammatory Bowel Disease: Relationship of Self-Compassion to Psychosocial and Physical Outcomes. This study offers preliminary support for the importance of self-compassion in AYAs with IBD and demonstrates the need for further research in this area. |
The Potential of Molecular Remission: Tissue Neutrophil Elastase Is Better Than Histological Activity for Predicting Long-Term Relapse in Patients With Ulcerative Colitis in Endoscopic Remission. In patients with UC who have achieved clinical and endoscopic remission, tissue expression of NE is a better predictor of long-term relapse than histological activity. |
| J Crohns Colitis |
HLA-DQA1*05 associates with anti-TNF immunogenicity and low adalimumab trough concentrations in inflammatory bowel disease patients from the SERENE UC and CD studies. We found a significant association between alleles at genes in the human HLA locus and the formation of adalimumab immunogenicity and low adalimumab drug-serum concentrations in large clinical studies of CD and UC patients. This work extends previous results in Crohn's disease to ulcerative colitis and directly shows a genetic association in patients with low drug concentrations. This work builds on existing literature to suggest genetic screening as a useful tool for clinicians concerned with patient anti-TNF immunogenicity. |
Peripheral Blood Eosinophilia at Diagnosis of Inflammatory Bowel Disease Is Associated with Severe Disease Course; A Nationwide Study From the epi-IIRN Cohort. In this largest nationwide study, PBE predicted severe IBD course. These findings support the use of PBE as a marker of adverse outcome of IBD and as a potential target for future therapies. |
Subcutaneous infliximab cut-off points in patients with inflammatory bowel disease. Data from the ENEIDA registry. Switching from IV-IFX to SC-IFX safely maintains long-term remission in patients with CD and UC. In maintenance, the optimal cut-off point associated with remission was 12-13 μg/mL. |
| Liver Transpl |
A scoping review of non-medical barriers to living-donor liver transplant. The scoping review underscores non-medical barriers to LDLT across recipient, donor, and provider levels. These barriers include socioeconomic disparities, information gaps, and inadequate institutional support. The findings underscore the need for comprehensive national efforts to raise awareness about LDLT and provide essential financial support. |
Development and validation of MRI PDFF Cut-offs for living liver donor eligibility assessment. For diagnosing histologic HS ≥30%, which is the most prevalently used threshold for LDLT donor eligibility assessment, the PDFF cut-offs achieved sensitivities and specificities of both over 90%. The equation of (Histologic HS=-2.95 + 1.93 * PDFF) was derived. |
Future of U.S. living donor liver transplant: Donor and recipient criteria, transplant indications, transplant oncology, liver paired exchange and non-directed donor graft allocation. With ongoing investment in the deliberate growth of LDLT surgical expertise, experience and technical advances in the U. S., the liver transplant community's future vision to increase transplant access to more patients with end-stage liver disease and selected oncology patients may be successfully realized. |
Hospital readmission for acute kidney injury is independently associated with de novo end-stage renal disease after liver transplantation. AKI readmissions in the first post-LT year impact over one-quarter of recipients. These increase the risk of subsequent ESRD, but may represent an opportunity to intervene and mitigate further renal dysfunction. |
Hypothermic oxygenated machine perfusion influences the immunogenicity of donor livers in humans. Our study provides novel mechanistic insight into the capacity of HOPE to influence liver IRI and to modulate effector and regulatory donor-specific T cell responses post-transplantation. These findings, which confirm observations made in animal models, help explain the decreased rejection rates reported in patients receiving HOPE-treated allografts. |
Informatics driven solutions for optimal care delivery in liver transplantation. In this review, we explore the utility of various techniques of clinical informatics mainly within the transplant care cascade, barriers to implementation, and highlight opportunities for future investigation and optimized use. Although barriers to widespread adoption remain such as interoperability, data access and availability and structured implementation strategies, the integration of informatics and CDS/AI-based tools into routine care for liver transplantation represents an opportunity for marked enhancement in how we deliver care to these patients. |
Liver transplantation for pediatric genetic and metabolic disorders. The decision to transplant can be challenging and requires consideration of several factors including hepatic involvement, extra-hepatic manifestations, and anticipated post-transplant outcomes. This review examines pediatric genetic and metabolic liver diseases, their pathophysiology, clinical presentation, and the role of liver transplantation. |
Liver transplantation for pediatric liver malignancies. Furthermore, LT has also shown better results than liver resection for cases of HCC not meeting Milan criteria. Given the rarity of pediatric liver malignancies and challenges in optimal management, a multidisciplinary treatment approach, research models building on what is already known, and consideration of newer treatment modalities are required for further improving the treatment of pediatric liver malignancies. |
MRI-serum-based score accurately identifies liver transplant patients without rejection avoiding need for liver biopsy: A multisite European study. Combining both imaging and serum biomarkers into a composite biomarker (imaging and serum biomarkers) has potential in monitoring the liver graft to effectively risk stratify patients and identify those most likely to benefit from a non-invasive diagnostic approach, reducing the need for liver biopsy. |
Reappraisal of tacrolimus levels post liver transplant for hepatocellular carcinoma: A multicenter study toward personalized immunosuppression regimen. Although previous studies have explored the influence of FK levels at 1 to 3 months post-LT on HCC recurrence, this current study suggests that earlier time points and exposure levels must be evaluated. Each patient's oncological risk must also be considered in developing an individualized immunosuppression regimen. |
The clinical relevance of the new criteria for cirrhotic cardiomyopathy and future directions. Since 2020, the prevalence of the disorder and clinical considerations for pre-transplant, peritransplant, and post-transplant patients with cirrhosis have been further evaluated and CCM was found to adversely impact clinical outcomes during al three phases of care. Future research considerations should address the timing of universal echocardiographic screening for patients with cirrhosis, utility of biomarkers in aiding CCM diagnosis, impact of CCM on right heart function, and role of anti-remodeling agents post-liver transplant (post-LT). |
| Pancreatology |
Molecular aspects of BRAF and HER2 in prognosis of periampullary carcinoma. BRAF V600E SNP was associated with disease susceptibility, and had increased mRNA expression while HER2 I1655V SNP was associated with poor survival outcome in PAC. The increased expression of BRAF and HER2 in early tumors and their co-expression in PAC exhibit cross talk between RAS/RAF and EGFR pathway in PAC. |
Prospective multicenter surveillance study of branch-duct intraductal papillary mucinous neoplasm of the pancreas; risk of dual carcinogenesis. Careful attention should be given to "dual carcinogenesis" during BD-IPMN surveillance, indicating the progression of BD-IPMN to HGD/IC and development of cPDAC distinct from BD-IPMN, although the establishment of risk factors that predict cPDAC development remains a challenge (UMIN000007349). |
Relationships between postoperative recurrences and standardized uptake value on 18F-fluorodeoxyglucose-positron emission tomography in patients with resectable and borderline resectable pancreatic ductal adenocarcinoma who underwent curative pancreatic resection after neoadjuvant chemoradiotherapy. R- and BR-PDACs with high SUV on FDG-PET at diagnosis are risk factors for postoperative recurrence. Among patients who undergo surgery after NACRT, those with a high SUVmax at diagnosis or post-NACRT require careful attention for postoperative liver recurrence. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Inflamm Bowel Dis |
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| J Crohns Colitis |
| Pancreatology |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Inflamm Bowel Dis |
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| Liver Transpl |
Letters to the editors and authors’ replies
| Inflamm Bowel Dis |
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| Pancreatology |